The COLOSTRUM It is the mixture produced by the mammary gland in the first 48-72 hours after the birth of the calf. Thanks to its particular composition, it guarantees the survival of many newborn mammals. Numerous experiments have shown that bovine colostrum has good contents of immunoglobulins (IgA, IgG and IgM), molecules with an antimicrobial action (lysozyme, lactoperoxidase, protease inhibitors and lactoferrin) as well as substances with an immunostimulant action (PRP and cytokines). In this regard, in recent years, it has been found that the administration of bovine colostrum to humans (very similar in composition to human colostrum), allows for an improvement in the subject’s immune function as well as tissue growth. Especially it has been shown that the more than 20 types of antibodies present in colostrum, as well as its content in Lactoferrin, Lysozyme and Lactoperoxidase,   help the body to repel viruses, bacteria and fungi such as: E. coli, Salmonella sp., Rotavirus, Candida sp., Staphylococcus sp., Streptococcus sp.,       Helycobacter pylori.  Several researchers have also reported that in addition to immunoglobulins, colostrum seems to contain a factor capable of strengthening an inactive immune system,   while tending to balance an overactive immune system. Another peculiarity of bovine colostrum is that it also contains other particularly interesting substances. Among these very important are polyamines and GLP1 and GLP2 molecules, for which many studies have shown their importance in the support a stabilizing action of the intestinal  barrier(stabilization of tight joints), improve the repair capacity of the gastro-intestinal tissue as well as prevent and promote recovery in case of peptic ulcer. Similarly, the presence of molecules supporting the functionality of fibroblasts, platelets and epithelial growth (EGF, FGF, PDGF) are able to ensure the natural processes of development and regeneration of enteric, hepatic and pancreatic epithelia. Finally, the content in glycine, histidine and taurine allows the bovine colostrum to exert an important antioxidant action able to prevent intestinal injuries by free radicals. Colostrum plays an important role in Leaky Gut Syndrome. Various dysfunctions affecting the gastrointestinal  system(H. pilory infection, intestinal dysbiosis, candidiasis and intestinal mycosis, intestinal parasitosis, inflammatory bowel disease, enteritis and celiac disease) are associated with a loss of competence of the gastrointestinal barrier. This condition, due to a loosening of the Tight and Aderence Junctions systems, is generally referred to as Leaky Gut/Stomach Syndrome . Consequence of LGS is the anomalous entry of microorganisms and heterologous substances into the connective tissue of the mucous membrane with exposure to deep and/or systemic infections and accumulation of toxins at the local and general connective tissue level. LGS is therefore a frequent condition that occurs in conjunction with the main GI disorders which, in addition to being an aggravating factor, hinders recovery during convalescence. In this context, the bovine colostrum, thanks to its content in polyamines, gastro intestinal polypeptides (GLP-1 and GLP-2) and factors stimulating the connective function (EGF, FGF and PDGF) help to counteract LGS and to promote the processes of recovery and tissue repair of the epithelium and connective tissue of the GI mucos tunic. In particular, many studies have shown that the Polyamines contained in Bovine Colostrum are able to favor the recovery of the full functionality of the cellular junction systems thus supporting the restoration of the barrier functionality. Furthermore, the simultaneous presence of polypeptides and growth factors for fibroblasts, epidermal cells and platelets (the latter capable of accelerating the recall of macrophages in damaged areas), as well as Histidine, Glycine and Taurine (Aminoacids with Scavenger action for Radicals free) are able to promote the recovery of the entire mucous  tunic(epithelium and connective) as well as producing an important detoxifying action.